CURRENT UNDERSTANDING ON PATHOGENESIS AND EFFECTIVE TREATMENT OF GLYCOGEN STORAGE DISEASE TYPE IB WITH EMPAGLIFLOZIN: NEW INSIGHTS COMING FROM DIABETES FOR ITS POTENTIAL IMPLICATIONS IN OTHER METABOLIC DISORDERS

Glycogen storage type Ib (GSDIb) is a rare inborn error of metabolism caused by glucose-6-phosphate transporter (G6PT, SLC37A4) deficiency.G6PT defect results in excessive accumulation of glycogen and fat in the liver, kidney, and intestinal mucosa and into both glycogenolysis and gluconeogenesis impairment.Clinical features include hepatomegaly, h

Coronary artery air embolization is a rare event leading to catastrophic hemodynamic compromise within seconds after introduction of air within the coronary arteries.The management of massive air embolism should be extremely lycogel quick so as to prevent cardiac compromise.In this report, we present a case of massive air embolism in the left anter

Abstract Background MicroRNAs (miRNAs) are implicated in the progression of ischemic stroke (IS) jolly rancher filled gummies and bone marrow-derived mesenchymal stem cells (BMSCs)-derived exosomes play a role in IS therapy.Herein we hypothesized that the BMSCs-derived exosomes containing overexpressed miR-138-5p could protect the astrocytes follow

Peptide-based vaccines have demonstrated to be an important way to induce long-lived immune responses and, therefore, a promising strategy in the rational of vaccine development.As to malaria, among the classic vaccine targets, the Apical membrane antigen (AMA-1) was proven to have important B cell epitopes that can induce specific immune response